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학술발표회초록보기

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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 New Advances in Metal-Mediated Alkylation and Fluoroalkylation Reactions

등록일
2011년 8월 29일 20시 13분 45초
접수번호
1652
발표코드
ORGN-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 14시 : 40분
발표형식
심포지엄
발표분야
유기화학 - Recent Trends in Organic Chemistry
저자 및
공동저자
David Vicic
University of Hawaii, United States

Here we present our efforts to understand at a fundamental level how transition-metals may better introduce alkyl and perfluoroalkyl groups into organic substrates. Such methods are needed as developmental pipelines for new drugs are predicted to contain an extraordinarily high percentage of fluorinated molecules. The trifluoromethyl group, in particular, is becoming a privileged group in medicinal chemistry yet many difficulties are associated with efficient ways to introduce this group into organic molecules. We report here that new copper and nickel complexes show promise for the development of catalytic methods of fluoroalkylation. New methods for the construction of C(alkyl)-C(alkyl) bonds are also of interest as we move “beyond the flatlands” in organic coupling reactions, and mechanistic details of these reactions will also be discussed.


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