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  • 08월 18일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제108회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The Electrophoretic Synthesis of Hydrogel-Nanoparticle Hybrid Materials for Potential Drug Delivery System

2011년 8월 30일 17시 07분 51초
MAT2-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 10시 : 05분
재료화학 - New Trends in Materials Chemistry
저자 및
연세대학교 화학및의화학과, Korea
We have successfully prepared homogeneous hybrid materials between biocompatible hydrogels and 2-dimensional layered metal hydroxide (LMH) nanoparticles through electrophoretic route; hydrogels are frequently utilized as topical drug delivery and LMHs are known as potential reservoir for controlled drug release. Hydrogels, either agarose or gelatin (1 ~ 2 % in Tris-Cl buffer of pH 7.4) was located in the center of electrophoresis chamber separating metal precursor solution at anode and base solution at cathode, respectively. Various composition of metal precursors solutions, such as Ni2+/Al3+, Ni2+/Ga3+, Zn2+/Al3+, and Zn2+ were tested in preparing nanohybrids between hydrogel and Ni2Al(OH)6CO3)0.5, Ni2Ga(OH)6(CO3)0.5, Zn2Al(OH)6(CO3)0.5, Zn5(OH)6(CO3)0.5 nanoparticles. According to the X-ray diffraction (XRD) patterns and X-ray absorption spectrum (XAS), it was exhibited that each hybrid material has nanoscipic LMH particles in it and their crystal structures are almost similar to that of conventionally prepared ones. The infrared spectra of hybrid materials showed characteristic absorption peaks attributed to the stretching modes of hydrogels or LMHs, showing that the physicochemical properties of each substances are not significantly affected through electrophoretic synthesis. The scanning electron microscopy (SEM) images of hybrid materials showed homogeneously dispersed nanoparticles in hydrogel matrix, while the simple mixture of conventionally prepared nanoparticles and hydrogel showed uneven distribution. In order to investigate the potential of the prepared hybrids as drug delivery systems, we loaded polyphenol molecules into the hybrid materials through soaking route and evaluated the time-dependent release patterns of polyphenol. As a result, the homogeneous hybrids showed more controlled drug release behaviors compared to each substance of hydrogel matrix and nanoparticle itself.