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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and Biological evaluation of Peripheral benzodiazepine receptor( PBR) ligands for the treatment of Alzheimer’s disease

등록일
2012년 2월 8일 17시 41분 55초
접수번호
0098
발표코드
MEDI.P-977 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
양하연, 배애님1, 태진성, 이지연2, 박병건3
연세대학교 화학과, Korea
1한국과학기술연구원 생체과학연구본부, Korea
2성신여자대학교 글로벌의과학과, Korea
3고려대학교 생명공학과, Korea
The benzodiazepine receptors can be divided, from the point of view of their cellular localization, into two groups: central benzodiazepine receptors (CBR) and peripheral ones (PBR). A peripheral benzodiazepine receptor is localized in many types of tissues, on the surface of the mitochondrial membranes (IMM-OMM). This receptor mediates various mitochondrial functions, including cholesterol transport and steroid hormone synthesis, mitochondrial respiration, mitochondrial permeability transition (mPT) pore opening and cell proliferation and apoptosis. Initial clinical trials have indicated that PBR ligands might be valuable in the treatment of psychiatric disorders and neurological desease such as alzheimer’s desease. Therefore, the PBR is targeted to develop alzheimer’s disease drug. As part of discovering novel PBR ligands, we designed and synthesized 38 compounds. The synthesized compounds were biologically evaluated against PBR. The detailed design, synthesis and biological evaluation of PBR ligands as alzheimer’s disease drugs will be presented.

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