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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Nanoparticle-amplified SPR Biosensors for Biological and Environmental Applications

2012년 2월 8일 18시 06분 13초
ANAL2-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 11시 : 30분
분석화학 - Recent Advances in Analytical Chemistry II
저자 및
경북대학교 화학과, Korea
Surface plasmon resonance (SPR) measurements of biomolecular interactions on the surface of thin gold films have emerged as one of the leading techniques for the fast, in-situ detection of a wide spectrum of biological targets. In this talk, we will highlight our latest efforts to develop ultra-sensitive and selective SPR biosensors with different sizes and shapes of biofunctionalized nanoparticles for biomedical and environmental applications. For example, we compare the amplification performance of three different nanoparticle shapes (nanocages, nanorods and quasi-spherical nanoparticles) for the enhanced SPR detection of thrombin in conjunction with a thrombin specific aptamer chip created with a thiol-modified calix[4]arene derivative. In addition to increasing the nanoparticle size, with each type used here possessing at least one dimension at ~40?50 nm, changing the shape also introduces the possibility of adjusting the localized plasmon resonance properties of the nanoparticle over a much larger wavelength range. As a second example, we demonstrate a simple surface sandwich SPR analysis that uses a combination of histidine coated quasi-spherical nanoparticles with a Ni(II) ion specific ligand, N-[5-(3’-maleimidopropylamido)-1-caboxypentyl]-iminodiacetic acid, coated SPR Au chip for the sub-ppb concentration range of Ni (II) ions.