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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Unimolecular Dissociation of Peptide Ions Facilitated by Laser-induced Surface Heating

등록일
2012년 2월 10일 14시 03분 57초
접수번호
0127
발표코드
PHYS2-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 16시 : 10분
발표형식
심포지엄
발표분야
물리화학 - New Trends in Physical Chemistry: Young Physical Chemist Symposium
저자 및
공동저자
한상윤
한국표준과학연구원 나노바이오융합연구단, Korea
We investigated the mechanical aspects involved in laser-induced thermal desorption of peptides from flat surfaces, in pursuit of new ionization that may offer an alternative to the conventional MALDI method. A comparative study on laser desorption/ionization (LDI) from surfaces with different thermal properties was carried out. In addition, the internal energies of resulting LDI ions were determined using a series of thermometry preformed ions, which was also compared with the MALDI method. The study revealed that thermal desorption promoted by laser-induced surface heating is the main driving force for the observed LDI processes of thermally labile molecules with large molecular masses. The results also indicated that laser-induced thermal desorption can further provide a means to increase the internal energies of generated peptide ions, giving rise to unimolecular decompositon of peptide ions. This work demonstrates that the thermal mechanism is indeed important for LDI of thermally labile molecules, and can also offer a way to cause a post-source decay, which is suitable for peptide sequencing using TOF/TOF mass spectrometry.

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