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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Fabrication of Si-encapsulated nanoprobes for SERS imaging of multiple protein markers expressed in live cells

등록일
2012년 2월 14일 10시 17분 18초
접수번호
0223
발표코드
PHYS.P-299 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
물리화학
저자 및
공동저자
이상엽, 전향아1, 주재범
한양대학교 생명나노공학과, Korea
1한양대학교 바이오나노공학과, Korea
Highly sensitive optical imaging technology using metal nanoparticles has been extensively applied to cellular imaging and biomedical diagnostics. Surface-enhanced Raman scattering (SERS), using the inelastic light scattering of gold or silver nanoparticles, is emerging as a powerful alternative for specific biological targets in live cells. It allows ultra-sensitive biochemical analysis in terms of multiplex targeting using individual spectral signatures or its combinations. Using the SERS technique, it is known that the detection sensitivity is enhanced up to 10?14 orders of magnitude over conventional Raman spectroscopy. Consequently, the SERS technique provides a sensitivity that is comparable with fluorescence detection. Raman mapping is a newly developed and noninvasive preclinical imaging technique that offers picomolar sensitivity and multiplex detection capabilities to the field of molecular imaging. In this study, we demonstrate the applicability of Raman imaging technique for the classification of three different types of protein markers expressed on breast cancer cells. Multiplex SERS imaging of protein markers on the surface of cancer cells has been carried out using newly developed core-shell SERS nanoprobes. All the SERS nanoprobes were successfully identified by UV/Vis, DLS, TEM, and SERS. The Raman mapping images using the SERS probes could be successfully used for the classification of three different cancer cell lines. The result shows a potential capability of the SERS imaging technique for the preclinical diagnosis of breast cancer.

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