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학술발표회초록보기

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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Anti-oxidative and Anti-inflammatory Constituents from the Branches of Malus sieboldii

등록일
2012년 2월 14일 15시 40분 51초
접수번호
0280
발표코드
MEDI.P-980 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
양인정, 오태헌, 김정은, 변상희, 김수영, 이남호
제주대학교 화학과, Korea
This study was designed to analyze the chemical constituents in the extract of Malus sieboldii branches and to evaluate their biological activities. Phytochemical investigation of the ethanol extract from M. sieboldii branches by using repeated column chromatography with normal-phase silica gel and Sephadex LH-20 resulted in the isolation of six compounds; β-sitosterol (1), epi-catechin (2), 3-O-α-L-arabinofuranosyl-8-methoxyquercetin (3), phlorizin (4), avicularin (5), and chrysin-7-O-β-D-glucopyranoside (6). The chemical structures of these compounds were confirmed by comparing their spectroscopic data to those in the literature. As far as we know, all of the compounds 1-6 were isolated for the first time from this plant. For the anti-oxidation tests, the compounds 2, 3 and 5 showed strong DPPH radical scavenging activities with SC50 of 15.7, 25.4 and 17.2 μg/mL respectively, whose activities were comparable to a positive control vitamin C (SC50 8.7 μg/mL). On the screening of anti-inflammatory activities, the compounds 2 and 6 showed the considerable inhibition on the production of nitric oxide for the RAW 264.7 cell without any cell toxicities. Based on these results, M. sieboldii branches extract could be potentially applicable as anti-oxidant and anti-inflammatory agent in cosmeceutical and/or pharmaceutical preparations.

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