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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Clinical use of near-infrared fluorescence: initial step in multimodal image-guided operation of cancer patient

2012년 2월 14일 15시 57분 44초
BIO2-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
금 11시 : 30분
생명화학 - Approaches of applied chemistry for translational research
저자 및
국립암센터 분자영상치료연구과, Korea
Although various 3D medical imaging techniques, such as CT, MRI, and ultrasound, have become available during the last few decades, surgeons primarily operate by the help of vision and touch. As these advanced imaging techniques could not be directly applied to the operation, other intra-operative/ real-time technology should be developed and applied. Radioisotope and fluorophore could be used for intra-operative guidance. At present, the most popular technique for intra-operative guidance is radio-guided method. Radio-guided method is the ‘gold-standard’ in clinical studies but has some drawbacks. It cannot offer visual information in the operation room. Whereas, fluorescence technique could give excellent visual information and it is suitable for the intra-operative usage. Although fluorescence has much potentiality, low energy photons associated with fluorescence imaging suffer significant attenuation by tissue absorption and scattering properties, as well as significant levels of auto-fluorescence. Near-infrared (NIR) fluorescence imaging, recently introduced, may have little or no auto-fluorescence as well as significant tissue penetration. Breast cancer is one of the most important women cancers in Korea. It is clinically important and relatively easy to apply multimodal image-guided operation to the breast cancer. We developed multimodal approaches for sentinel lymph node mapping using dye, NIR fluorescence and radioisotope. We started clinical research for this multimodal sentinel lymph node mapping. We expect to disclose our method to be more surgeon-friendly and diagnostically better than conventional method.