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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Optimization Process of a Novel 3-Arylethynyl-substituted Thieno[2,4-b]pyrazine Derivatives as a Wnt/β-catenin Pathway Inhibitors

등록일
2012년 2월 14일 19시 23분 33초
접수번호
0334
발표코드
MEDI.P-985 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
김나연, 곽세훈, 이은실1, 공영대
동국대학교 화학과, Korea
1동국대학교 의약화학연구실, Korea
The Wnt signaling is one of the key signaling pathways that regulate cell proliferation, differentiation, and morphogenesis. Wnt proteins constitute a family of highly conserved secreted glycoproteins that play multiple roles in the development and progression of diseases. Small-molecule inhibitors of this pathway are desired because it is believed their clinical use would suppress cancer cell growth. As a result, there has been an interest in identifying small molecule inhibitors of Wnt signaling as tool compounds for research or as precursors to new generations of anticancer drugs. Several potent small-molecule inhibitors have been reported; however, the development of therapies to specifically target the Wnt pathway in cancer cells is still in its infancy. To identify small molecule inhibitors of Wnt/β-catenin pathway, we are screening 3-arylethynyl-substituted thieno[2,4-b]pyrazine derivatives

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