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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Solid-phase Synthesis of 2-Amino/Amido/Sulfonamido Substituted-1H-benzo[d]imidazole Derivatives via Thiourea Linker on BAL Resin

등록일
2012년 2월 14일 19시 23분 35초
접수번호
0335
발표코드
MEDI.P-986 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
이지형, 정세린, 양정원, 공영대
동국대학교 화학과, Korea
Combinatorial chemistry of small organic molecules in solution phase or on solid support has a significant impact on the drug discovery. And heterocyclic compounds are commonly used scaffolds on which pharmacophores are arranged to provide potent and selective drugs. In this regard, because 2-amino/amido/sulfonamido substituted benzo[d]imidazole derivatives have attracted much attention for their interesting biological activities such as COX-2, 5-LO and various receptor antagonistic, they serve as attractive targets for combinatorial library construction via solid-phase synthesis. Therefore we have been exploring the potential of resin-bound benzo[d]imidazole derivatives as a versatile intermediate for generation of drug-like heterocyclic compound libraries. Herein we would like to present novel solid-phase synthetic method for combinatorial generation of benzo[d]imidazole based library through resin-bound BAL linker. Especially, we will discuss about solid-phase synthetic route to a unique substituted benzo[d]imidazole derivatives based on diverty oriented synthesis concept. The final compounds were obtained in good yields and high purities upon cleavage from the resins.

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