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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Construction of a Novel drug-like 2-Thioxoimidazolidin-4-one Derivatives using Various Amino acids via Isothiocyanate linker on Solid-phase

2012년 2월 14일 19시 23분 58초
MEDI.P-989 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 25일 (수요일) 18:00~21:00
저자 및
이재민, 배미선, 김용상, 공영대
동국대학교 화학과, Korea
The factor of success in innovative drug search depends on how many we have the various and creative drug like library. The compounds equipped with the molecular diversity, there are also more probability to find the new drug. The solid phase synthesis of heterocyclic combinatorial libraries is a strategy to have drug discovery process. And Solid-phase synthesis of heterocyclic core skeleton serve as the core components of a large number of substance that process a wide range of interesting biological activities. As a part of our ongoing drug discovery program, we have been exploring a potential of resin-bound thioxoimidazolidine-4-one derivatives since they are easily obtained from various natural amino acids. In this present, we would like to present a convenient solid-phase synthetic method for combinatorial generation of 2-thioxoimidazolidine-4-one derivatives through resin-bound benzyl thiocyanate linker on BAL resin. The 2-thioxo imidazolidine derivatives have attracted much attention since it have been reported to be responsible for interesting biological activities such as Hif?1α and Wnt signal path way, and various receptor antagonist. Through making the various substituted aromatic building blocks, we can obtain linear compound. The final compounds were obtained in good yield and high purities from solution-phase synthetic process.