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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Solid-phase Synthesis and Cyclization Reactions of Novel Pyrazole Derivatives via Hydrazine Linker on AMEBA Resin

등록일
2012년 2월 14일 19시 24분 00초
접수번호
0340
발표코드
MEDI.P-991 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
곽현정, 김나연, 이원주, 공영대
동국대학교 화학과, Korea
Solid-phase synthesis of combinatorial chemistry has emerged as a powerful methodology for the preparation of libraries of small organic compounds in order to accelerate the drug discovery process. And heterocyclic compounds serve as ideal scaffolds on which pharmacophores can be appended to yield potent and selective drugs. As a part of an ongoing drug discovery program, we have been exploring the potential of new and highly efficient synthetic methods for various resin-bound pyrazole derivatives as a versatile intermediate for generation of drug-like heterocyclic compound libraries. Herein we would like to present novel solid-phase synthesis for combinatorial generation of pyrazole based libraries through resin-bound hydrazine linker on AMEBA resin. During the past decade 1,3,4,5-substituted pyrazole derivatives of five-member ring heterocyclic compounds have attracted much attention for their interesting biological activities such as COX-Ⅱ inhibitors, 5-LO inhibitors, and various receptor antagonistics. The progress of reactions could be monitored as resin-bound intermediates by ATR-FTIR spectroscopy. The final compounds were obtained in good yields and high purities upon cleavage from the AMEBA resin.

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