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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of New Derivatives of Purpurinimide and Chlorin Amide Encapsulated in Biogradable Polymer

등록일
2012년 2월 15일 11시 02분 30초
접수번호
0401
발표코드
MEDI.P-996 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
김정화, 윤일1, 심영기2
인제대학교 나노시스템공학과, Korea
1인제대학교 PDT 연구소, Korea
2인제대학교 나노공학부, Korea
Hydrophobic agents have a good cellular invasion. But on the other hand, a major disadvantage of hydrophobic agents is that time of absolutely removal of the materials from the body is so slow. Hydrophilic agents are quick to out of body, but it cannot penetrate cell wall unlike hydrophobic ones. For the purpose of the effect, we had an idea as follows. First step, we made two hydrophilic photosensitizers. Chlorine e6 13(1)-N,N-dibutylamide was synthesized by dibutyl amine group and carboxylic group. These materials were encapsulated into poly lactic-co-glycolic acid (PLGA) nanoparticles together. Size of this nanoparticle is less than 230 nm. The PLGA outer layer, hydrophobic biological polymer, facilitated cellular invasion causing endocytosis. And then, PLGA layer disintegrated through the acidity of tumor cell. So the hydrophilic photosensitizers could be delivered into the tumor cell.

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