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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Identification of Anti-oxidative and Anti-inflammatory Constituents from the Branches of Carpinus turczaninowii

등록일
2012년 2월 15일 11시 45분 19초
접수번호
0415
발표코드
MEDI.P-998 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
고하나, 김상숙1, 김성천, 한정환, 강지미, 이라겸, 이남호
제주대학교 화학과, Korea
1국립원예특작과학원 감귤시험장, Korea

Carpinus turczaniowii is a tree belonging to Betulaceae family. Phytochemical investigation of the ethanol extract from branches of C. turczaniowii by using repeated column chromatography resulted in the isolation of eight compounds; β-sitosterol (1), daucosterol (2), betulinic acid (3), pyracrenic acid (4), carpinontriol B (5), carpinontriol A (6), afzelin (7) and quercitrin (8). The structures of these compounds were identified by spectroscopic methods and by comparing their data to those in the literature. As far as we know, all of the compounds except quercitrin (8) were isolated for the first time from this plant. The isolated compounds were also subjected to the activity screenigs on anti-oxidation and anti-inflammation. For the anti-oxidation tests, the compounds 4 and 8 showed strong DPPH radical scavenging activities with SC50 of 55.2 and 62.4 μM respectively, whose activities were comparable to a positive control vitamin C (SC50 43.5 μM). In addition, compounds 4, 5, 6 and 8 showed strong ABTS+ radical scavenging activities with SC50 of 34.1, 42.1 45.8 and 29.6 μM respectively, indicating comparable activity to vitamin C (SC50 31.6 μM). On the screening of anti-inflammatory activities, the compounds 5 and 6 showed the considerable inhibition on the production of nitric oxide for the RAW 264.7 cell without exhibiting cell toxicities. Based on these results, C. turczaninowii branch extract could be potentially applicable as anti-oxidant and anti-inflammatory agents in cosmeceutical and/or pharmaceutical preparations.


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