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학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthetic studies on new 2-nitroimidazole derivatives with isoxazole and oxime structures for imaging tumor hypoxia

등록일
2012년 2월 15일 16시 09분 47초
접수번호
0518
발표코드
MEDI.P-999 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
최정화, 이해황, 고훈영
인하대학교 화학과, Korea
Tumor hypoxia is the biological situation where tumor cells have been deprived of oxygen. The detection of hypoxia cell is important for treatment planning, such as in cases of cancer or myocardial ischemia. A number of isotopically labeled 2-nitroimidazole derivatives have been investigated as potential hypoxia markers. The nitro-aromatic classes of bio reductive derivatives were developed on the basis that the nitro functionality of the compound is able to be reduced under hypoxic conditions. Since 2-nitroimidazole heterocycles is the key structure in the field of imaging of hypoxia, it is important to introduce this 2-nitroimidazole ring for the discovery of new compounds. As part of discovering new imaging ligands, new 2-nitroimidaxole with isoxazole and oxime isomers containing fluorine and primary alcohol functionality were designed and synthesized. The basic concept, design and synthetic efforts of the target structures as possible hypoxia imaging ligands will be presented.

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