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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Electrochemical Immunoassay for detecting hippuric acid at ITO electrodes modified by electrodeposition of nickel pentacyanoferrates-antigen conjugates

등록일
2012년 2월 15일 17시 18분 06초
접수번호
0568
발표코드
ELEC.P-1234 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
전기화학
저자 및
공동저자
전원용, 최영봉1, 김혁한1
단국대학교 나노바이오의과학과, Korea
1단국대학교 화학과, Korea
Electrochemical immunoassay for rapid and quantitative detection of hippuric acid (HA) in human urine was proposed in this work. The electrochemical immunoassay system for clinical diagnosis(or selectivity detection) has several advantages such as, simple instrumentation, relatively low cost, miniaturization, portability, disposability, and fully automation. The series of novel, formation of antigen-conjugated ferrate-nickel nanocomposite (Ni-Fe-HA) was electrodeposited onto indium tin oxide (ITO) electrode and then characterized using the electrochemical techniques. Also, the surface of the Ni-Fe-HA-electrodeposited on ITO electrode were identified by SEM image. The interaction between Os-HA-Bpy conjugate antigens and antibody-HA (anti-HA) was performed by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The redox currents of osmium complexes were linearly proportional to urinary HA in the range of 0.01 ~ 5.0 mg/mL, which is sufficient for use as an immunosensor using a cutoff concentration of 2.0 mg/mL in urine samples. The proposed electrochemical immunoassay method can be extended to various applications for detecting a wide range of different small antigens in the health care area.

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