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  • 08월 24일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

Synthesis and in vivo evaluation of cyclen-based Cu(II) complex as a diagnostic agent for Dubin-Johnson syndrome

등록일
2005년 8월 19일 15시 38분 35초
접수번호
1014
발표코드
토21I7구 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
토 11시 : 20분
발표형식
구두발표
발표분야
무기화학
저자 및
공동저자
유정수, Michael J. Welch1
경북대학교 분자의학과,
1Washington University School of Medicine,
Dubin-Johnson syndrome (DJS) is caused by a deficiency of the human canalicular multispecific organic anion transporter (cMOAT). A new lipophilic copper-64 complex of 1,4,7-tris(carboxymethyl)-10-(tetradecyl)-1,4,7,10-tetraazadodecane was prepared and evaluated for potential as a diagnostic tool for DJS. The prepared ligand was labeled with 64Cu-citrate in high radiochemical purity. In vivo uptake and clearance of the complex was determined through biodistribution studies using normal Sprague-Dawley rats and mutant cMOAT-deficient (TR-) Wistar rats. In normal rats, the radioactive copper complex was cleared quickly from the body exclusively through the hepatic pathway. While activity was accumulated continuously in the liver of TR- rats, it was not excreted into the small intestine. MicroPET studies of normal and TR- rats were consistent with biodistribution data and showed dramatically different images. The significant difference between the microPET images of the normal and TR- rats demonstrates that this new 64Cu complex may allow noninvasive diagnosis of DJS in humans.
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