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Chiral N-acylated 4-isopropyl-5,5-diphenyl-2-phenylamino-2-oxazolines readily from L-Valine methyl ester in three steps, have been demonstrated to undergo highly diastereoselective alkylations via their lithium enolates. Removal of the chiral auxiliaries to produce the acid, ester, amide and aldehyde without compromising the stereochmical integrity will be discussed.
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KCS
