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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis, Urease Inhibition, Antioxidant and Antibacterial Studies of Some 4-Amino-5-aryl-3H-1,2,4-triazole-3-thiones and their 3,6-Disubstituted 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole Derivatives

등록일
2012년 2월 16일 17시 43분 18초
접수번호
1266
발표코드
MEDI.P-1020 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
Muhammad Hanif, Muhammad Saleem, Muhammad T. Hussain1, Nasim H. Rama, Sumera Zaib2, Muhammad Adil M. Aslam2, Peter G. Jonesd2, Jamshed Iqbal2
Department of Chemistry, Quaid-i-Azam University, Pakistan
1Department of Applied Sciences, National Textile University, Pakistan
2Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Pakistan
A new series of 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones, bearing various methoxybenzyl and methoxyphenethyl groups, was synthesized by refluxing potassium hydrazinecarbodithioate salts in dilute aqueous solution of hydrazine hydrate. These salts were formed by the reaction of acid hydrazides and carbon disulfide in methanolic potassium hydroxide solution at 0-5 °C. 4-Amino-5- aryl-3H-1,2,4-triazole-3-thiones were condensed with different substituted aromatic acids to yield 3,6-disubstituted-1,2,4 triazolo[3,4-b]1,3,4-thiadiazoles. The structures of the newly synthesized compounds were characterized by infrared (IR), 1H and 13C nuclear magnetic resonance (NMR) spectroscopies, elemental analysis and mass spectrometric (MS) studies. Structure of one of the compounds was further confirmed by single crystal X-ray diffractometry (XRD). All the synthesized compounds were screened for their urease inhibition, antioxidant and antibacterial activities. Some compounds showed excellent urease inhibition activity, more than the standard drug. Others exhibited potent antioxidant activity. All the compounds showed significant antibacterial activities as compared to standard drug.

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