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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Cucurbit[6]uril and Spermine Interaction Measured by Force-Based Atomic Force Microscopy

등록일
2012년 2월 16일 20시 21분 01초
접수번호
1274
발표코드
INOR.P-243 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
무기화학
저자 및
공동저자
배영인, 백강균, 김기문, 박준원
포항공과대학교 화학과, Korea
Atomic force microscopy (AFM) has been generally used to study specific interaction between host-guest complexes as well as biomolecule pairs. We measured the single unbinding force of a host-guest complex, cucurbit[6]uril (CB[6]) and spermine. To observe unbinding event of the complex at a single molecule level, a dendron was immobilized on both an AFM tip and a substrate. Subsequently, a dendron-coated tip was functionalized with spermine. And bovine serum albumin (BSA) was introduced on the dendron-coated substrate before the immobilization of CB[6]. Under the condition, a characteristic stretching in the force-distance curve showing single unbinding force was observed due to the elasticity of the protein. Also, an adhesion force map was obtained. With these approaches, unambiguous sorting the specific unbinding event, and observing hydrodynamic behavior of CB[6] based on a BSA substrate were possible.

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