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학술발표회초록보기

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제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of Norlignan Derivatives and Inhibitory Effect of Antigen-Induced Degranulation

등록일
2012년 2월 23일 15시 23분 18초
접수번호
1453
발표코드
ORGN.P-952 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 25일 (수요일) 18:00~21:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김인수
경희대학교 약학과, Korea
Norlignans are abundant in the heartwood of many coniferous trees and in some monocotyledonous plants, and possess a wide spectrum of biological activities such as anti-cancer/anti-inflammatory, anti-complement, anti-fungal activity, testosterone 5α?reductase inhibition, and cyclic AMP phosphodiesterase inhibition. Naturally occurring norlignan are a class of natural phenolic compounds with diphenylpentane carbon skeletons (C6?C5?C6). Hinokiresinol, the E-isomer of nyasol, is a typical example of such a norlignan. Hinokiresinol was first isolated from the heartwood of Chamaecyparis obtuse in 1965, and was found to display appreciable estrogen receptor binding activity and some antiplasmodial activity. We recently found that nyasol and its derivatives, isolated from Anemarrhena asphodeloides, act as powerful inhibitors of antigen-induced degranulation, and have the potential to be useful therapies for allergic disorders such as asthma and atopic dermatitis. In view of these interesting biological activities of norlignans, we report here the inhibitory activity of hinokiresionol derivatives including synthetic intermediates on antigen-induced degranulation.

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