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학술발표회초록보기

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  • 03월 02일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제109회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Ultrasensitive and Label-free Detection of Annexin A3 Based on Quartz Crystal Microbalance

등록일
2012년 2월 23일 15시 58분 14초
접수번호
1462
발표코드
PHYS.O-12 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 12시 : 00분
발표형식
구두발표
발표분야
물리화학 - General Oral Presentation
저자 및
공동저자
Md. Mahbubur Rahman
건국대학교 신기술융합학과 , Korea
A detection method for the lung cancer and prostate biomarker protein annexin 3 (ANXA3) was developed using simple label-free ultrasensitive quartz crystal microbalance (QCM) immunosensor based on a quantum dots (QDs) nanoprobe. The QDs nanoprobe was fabricated by covalently attaching carboxylic acid group functionalized cadmium sulfide (CdS) quantum dots on the mixed cystamine (CYS) and mercaptoethanol (MCE) self-assembled monolayer (SAM). Anti-ANXA3 antibody was covalently immobilized on the carboxylic acid group functionalized QDs through the formation of amide bond. The resultant CYS-SAM/QDs/Anti-ANXA3 immunosensor probe was used to detect ANXA3 by monitoring the frequency change. Under the optimized condition, the ANXA3 immunosensor showed a dynamic range between 0.075 and 50 ng/mL with a detection limit of 0.075 ? 0.01 ng/mL (75 ? 10 pg/mL). The immunosensor could detect ANXA3 as low as 0.1 ng/mL in spiked human blood and urine samples in 15 min without any interference from other proteins.

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