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학술발표회초록보기

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  • 09월 12일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제110회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Nano-emulsification of Pseudo-ceramide through Co-assembly with Glycolipid Biosurfactants

등록일
2012년 8월 27일 10시 04분 11초
접수번호
0281
발표코드
IND.P-122 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
공업화학
저자 및
공동저자
김민경, 정은선
한양대학교 응용화학과, Korea
It has been known that ceramide molecules in the stratum corneum layer form a thin lipid membrane with other biocomponents, including lipids, cholesterol, and free fatty acids. This membrane, which is either parallel or curved, plays an essential role in fulfilling epidermal barrier function by protecting trans-epidermal water loss as well as influx of environmental irritants. However, in usual complex formulations, ceramide molecules display strong intermolecular attractions, thus leading to serious phase separation from the system. This unique behavior of ceramide hampers much wider application in industry. This study introduces a robust and straightforward method for fabrication of stable pseudo-ceramide nanoparticles through co-assembling with a biosurfactant. The biosurfactant considered in this study is the mannosylerythritol lipid. It has a unique molecular structure consisting of a mannosylerythritol as a hydrophilic part and two alkyl chains with different number of carbons as hydrophobic moieties. We have found that this biosurfactant can assemble with pseudo-ceramide molecules due to the hydrophobic attraction, while its asymmetric molecular geometry disturbs formation of perfect lamellar structure of ceramide molecules. This allows us to obtain a very fine dispersion of ceramide nanoparticles in water. We show how our biosurfactant affects ceramide nano-particulation by observing phase miscibility, particle morphology, and suspension stability.

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