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학술발표회초록보기

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  • 09월 12일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제110회 대한화학회 학술발표회, 총회 및 기기전시회 안내 BODIPY and zinc-based fluorogenic compounds for molecular recognition

등록일
2012년 8월 30일 14시 22분 06초
접수번호
1167
발표코드
INOR1-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 10시 : 00분
발표형식
심포지엄
발표분야
무기화학 - Recent Advances in Coordination and Organometallic Chemistry
저자 및
공동저자
D.G.Churchill
KAIST 화학과, Korea
In this presentation, the synthesis and utility of certain BODIPY and non-BODIPY chemosensors will be discussed bearing (i) thienyl/furyl rotor attachments where probing is centered at the aromatic ring chalcogen atom, and (ii) arene rotor attachments where the heteroatom is external to the ring and used in sensing or in formation of alternate fluorophore skeletons. While we will go through a variety of results, some newer results are listed below: (A) Bis-arylsulfide BODIPY systems were prepared and studied for multiple Oxygen-atom sensing (at 522 nm) at the meso group position; 2- or 3-atom loading was optimal (50-fold, “turn-on”). Neuronal studies showed greater H2O2 sensitivity than 2’,7’-dichlorofluorescein diacetate. Mercury detection was also examined with this class and there was found to be an Hg2+ "AND" superoxide correspondence. The novel 1,3,6-trimethyl BODIPY was discovered as a biproduct under Lindsey conditions. (B) In related work, a novel fluorescent difluoroboroazaoxobenzazulene dye was synthesized from commercially available substrates in “one pot;” it was characterized structurally and spectroscopically, derivatized, and finally compared to a related BODIPY system that demonstrates “turn-on” H+ (42-fold) and F- (~5-fold) responses. (C) Fluorescence 'OFF-ON' behavior with addition of biological phosphate and Zn2+ was studied with Zn2(slys)2Cl2 [H2slys = 6-amino-2-{(2-hydroxybenzylidene)amino}hexanoic acid], a fluorescent water soluble complex, using various spectroscopic tools (e.g., 31P NMR, UV-Vis, emission and CD spectroscopy) at the mM level. Adduct-dependent fluorescence intensity changes can be interpreted as a two-input (cation / anion) implication molecular logic gate system. A displacement study of PPi (versus diphosphate and triphosphates) from the dizinc complex is also reported. Related work also involved assays with the proteins implicated in Parkinson’s Disease aetiology. Copper analogues of the zinc species were also used in substrate recognition and intriguing crystal packing effects in the solid state.

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