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학술발표회초록보기

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  • 09월 12일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제110회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and evaluation of IR3535 derivative as mosquito repellents

등록일
2012년 8월 30일 15시 54분 04초
접수번호
1383
발표코드
MEDI.P-1196 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
이지훈, 이진호
계명대학교 화학과, Korea
Diseases that are vectored by mosquitoes are encephalitis caused by Culex sp., malaria caused by Anopheles sp. and dengue fever caused by Aedes sp. These diseases infect over 700 million people each year; among these diseases, in the case of malaria, over 1 million deaths per year can be attributed to the disease, and over 3,000 people die every day due to malaria. Although as an organic compound DEET (N,N-Diethyl-meta-toluamide) is the most widely used as a general-purpose repellent ingredient, it has had problems such as safety due to its high skin permeability and issues of unpleasant odors, etc. Recently an eco-friendly natural materials IR3535 (ethyl 3-(N-butyl-N-acetyl)aminopropionate) has been used as an substitute for DEET, but it has drawbacks such as short duration time and lower activity. As a result, the development of a novel mosquito repellent which is active against mosquito while safe to human body is needed. In this study, we tried to find a new repellent ingredient with high potency and low toxicity. As an initial step, the derivatives of IR3535 were synthesized and tested for its repellency. After screening, LJH158 was found to be a promising candidate. Comparative repellent studies and toxicity tests were performed to confirm the potential of LJH158 as a new repellent ingredient.

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