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  • 09월 12일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제110회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthetic approach toward Resiniferatoxin and Kirkinine Core Structure

등록일
2012년 8월 30일 16시 11분 49초
접수번호
1436
발표코드
ORGN.P-1070 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
Ahmed H. E. Hassan, 이재균1, 민선준2, 조용서3
과학기술연합대학원대학교 화학과, Egypt
1한국과학기술연구원 케모인포매틱스연구단, Korea
2한국과학기술연구원 뇌의약연구단, Korea
3한국과학기술연구원 생체과학연구본부, Korea
Resiniferatoxin and Kirkinine belong to daphnane orthoesters group of molecules. They consist of tricyclic core structure having tetradecahydrobenzo[e]azulene ring system. Binding of resiniferatoxin (RTX) to the transient receptor potential cation channel subfamily V member 1 (TRPV1) stimulates and then inactivates heat and vanilloid-responsive nerve endings involved in heat and inflammatory pain signaling. RTX causes to become permeable to cations, most particularly the calcium cation; this evokes a powerful irritant effect followed by desensitization and analgesia. Kirkinine has a remarkable neurotrophic activity. It demonstrates nerve growth factor (NGF) like activity at nanomolar concentrations. It effectively promotes neuronal survival against serum deprivation in nanomolar concentrations. As a result, kirkinine and its analogs present very promising therapeutic opportunities against neurodegenerative diseases such as Alzheimer’s. In an attempt to develop a diverted total synthesis program for synthesis of the core structure of resiniferatoxin and kirkinine, we suggest possible synthetic strategies based on [3+4] cycloaddition reactions. Herein, we will report our current progress toward synthesis of the core tricyclic structure of the title compounds.

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