abs

학술발표회초록보기

초록문의 abstract@kcsnet.or.kr

결제문의 member@kcsnet.or.kr

현재 가능한 작업은 아래와 같습니다.
  • 09월 12일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제110회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Iron Oxide Nanoparticles Mediated Cancer Imaging and Therapy

등록일
2012년 8월 30일 16시 19분 46초
접수번호
1459
발표코드
MEDI.P-1199 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
의약화학
저자 및
공동저자
채민경, 이철현
한국기초과학지원연구원 자기공명연구부, Korea
Iron oxide nanoparticles as magnetic resonance imaging (MRI) contrast agents have a variety of characteristics that penetrate effectively biological membranes, circulate for a long time in blood vessel, and conjugate with targeted peptides. We synthesized nontoxic cleaved iron oxide nanoparticles (CION) from hydrophobic FeO nanoparticles (HION) via 3 steps. It showed improved r2 relaxivities and potential application as a drug delivery system by surface modification. Peptides are valuable targeting probes and therapeutic molecules because of their small size and low immunogenicity. CION was introduced two types of peptide, RGR peptide and polo-like kinase 1 (PLK 1) targeted peptide, for targeting and therapy cancer. A tumor-homing peptide (RGR peptide) is specifically binding to PDGF receptor-beta on endothelia cells of solid tumor. It was reported that inhibition of PLK1 which is a regulator of cell growth by using PLK1 targeted peptide cause tumor cell death but not normal cell. By selectively binding to cancer cell and inhibiting PLK1, these nanoparticles could be multi-modality imaging agents.

상단으로