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학술발표회초록보기

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  • 09월 12일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제110회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis of novel molecular frameworks containing two distinct heterocyclic cores in a single molecule with enhanced 3-dimensional shape diversity

등록일
2012년 9월 5일 11시 33분 58초
접수번호
1679
발표코드
ORGN.P-1109 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
임동현, 박승범1
서울대학교 생물물리 및 화학생물학과, Korea
1서울대학교 화학부, Korea
The synthesis of fused-triazole scaffolds that are connected with prymidine, pyrazole, or pyrazolopyrimidine through carbohydrate-derived stereodivergent linkers is reported here. Prymidine, pyrazole, or pyrazolopyrimidine-based carbohybrid was constructed through the condensation of the key intermediate, 2-C-formyl glycals, with various dinucleophiles. Fused-triazole scaffolds were constructed through the intramolecular 1,3-dipolar cycloaddition after functionalization of the hydroxyl groups of the carbohybrid with azide and alkyne functionality using SN2-type alkylation or Mitsnobu reaction. Overall, the synthetic method described here afforded two distinct privileged structures in a single molecule, conserving the stereogenic centers of the carbohydrates. In addition, the stereodivergent diol functionality at the linker position was modified to obtain chemical collections with maximized 3-dimensional shape diversity.

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