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학술발표회초록보기

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  • 09월 12일 17시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제110회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Intercalation of nicotinamide into the layered aluminosilicates for the controlled release

등록일
2012년 9월 5일 15시 44분 51초
접수번호
1712
발표코드
MAT.P-1382 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
류현주, 양재훈, 최진호
이화여자대학교 화학.나노과학과, Korea
Nicotinamide, a part of the water soluble vitamin B group, has a variety of pharmaceutical and dermatological functions such as effective skin whitening, anti-inflammatory, and anti-axiety properties, etc.. However, high dose nicotinamide is considered as a toxic drug. Therefore, in order to add slow and sustained release property to nicotinamide, we have incorporated nicotinamide into layered aluminosilicates (montmorillonite) by intercalative ion-exchange reaction at 80 oC by using protonated montmorillonite. According to the x-ray diffraction analysis, the basal spacing of nicotinamide-montmorillonite nanohybrid was determined to be 1.5 nm compared to that of Na+ intercalated montmorillonite (0.96 nm), indicating that nicotinamide was successfully intercalated into the interlayer space of montmorillonite. From the thermogravimetric analysis, the content of nicotinamide stabilized in the montmorillonite lattice was estimated as ~ 15 wt%. In the present study, an attempt has been made to control the release behavior of nicotinamide out of montmorillonite lattice by coating the nanohybrid with polymer. The release behavior of nicotinamide from the nanohybrids was investigated in the phosphate buffer solution of pH 7.

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