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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Highly Selective Detection of Mitochondrial Copper in Liver Cells with a Novel Fluorescent Probe

2013년 2월 14일 16시 23분 29초
ORGN.P-808 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 17일 (수요일) 16:00~19:00
저자 및
이윤학, 강철훈1,*, 김종승*
고려대학교 화학과, Korea
1경희대학교 동서의학대학원, Korea
Nature has originated sophisticated machinery to control the activities of essential trace elements, which contain enzymes, cofactors with catalytic functions, and structural support elements in human beings. Among these elements, copper is the third most abundant essential trace element in a variety of biological process and can be generally found as Cu2+ in living environment. However, unbalanced uptake of copper homeostasis can cause many human diseases, especially liver disease with long-term exposure. Thus, developments of sensitive techniques for the detection of Cu2+ from pollutants are very important to prevent poisoning in environmental and biological fields. Here, we present the design, synthesis and evaluation of a novel fluorescent probe for imaging labile copper level in liver mitochondria. This probe consists of naphthalimide with a copper chelator to provide a selective and sensitive fluorescence quenching with copper. Further, it is a multifunctional probe that incorporates a single galactose moiety as hepatocyte targeting unit, and a triphenylphosphonium ion as mitochondria-specific targeting unit. The ability to recognize real-time copper fluxes in living cells offers potentially opportunities to monitor copper in biological systems.