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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Asymmetric synthesis of cyclic γ-amino acids with five-membered ring constraint

등록일
2013년 2월 14일 16시 30분 01초
접수번호
1208
발표코드
ORGN.P-811 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
정윤식, 강필재, 최수혁*, 최문근, 정낙철1
연세대학교 화학과, Korea
1고려대학교 화학과, Korea
Synthesis and studies of unnatural amino acids have been of interest to chemists for decades. Since γ-amino acids play an important role in nervous system, they have intrigued many scientists following Seebach and Hanessian’s studies. Moreover, γ-amino acids are the key of treatment of disease related to neuro-system such as Parkinson's disease and Alzheimer's disease. To synthesize cyclic gamma amino acid stereoselectively, Methyl 2-(2-oxocyclopentyl) acetate and 1-phenylethylamime(PEA) were used as starting materials and sodium triacetoxy borohydride was used as reducing agent. The structurally-restricted and stable products were obtained in two ways; 1)Direct reductive amination, 2)Indirect reductive amination in two steps (imine preparation followed by reductive amination). The other starting material was tested to compare with non-protecting reactant. Diverse solvents, acids and different temperature conditions have also been tested.

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