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학술발표회초록보기

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제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Spectroscopic characterization of inclusion complex of drugs or mycotoxins with beta-cyclodextrin thiolate-decorated gold nanoparticles

등록일
2013년 2월 14일 16시 31분 11초
접수번호
1211
발표코드
ANAL.P-554 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
우린토야, Ganbold Erdene Ochir, 주상우
숭실대학교 화학과, Korea
We fabricated doxorubicin (DOX) or other mycotoxin-assembled beta-cyclodextrin thiolate (beta-CD-SH) on gold nanoparticles (AuNPs). The inclusion of DOX to beta-CD-SH and their subsequent adsorption on the AuNP surfaces was characterized using Raman, UV-Vis absorption, quasi-static light scattering, and infrared spectroscopy. A micromolar range of DOX loading is estimated for either 5 nm or 18.5 nm AuNP particle platform covered by beta-CD-SH. The fluorescence recovery test indicated that the attached DOX released from AuNPs after treatment with not serum media but 2 mM glutathione (GSH). Fluorescence microscope imaging indicated that the DOX was released from AuNPs in the cervical cancer HeLa cells after the endocytosis. We performed a cell viability assay for the anticancer drug-AuNP conjugates in the delivery to HeLa cells. A cytotoxicity test indicated that the DOX/beta-CD-SH/AuNPs system reduced the cell viability, whereas a comparable amount of AuNPs did not show any noticeable cytotoxicity. Our characterization may be useful to design the anticancer therapy based on AuNPs and CDs. We plan to develop a new spectroscopic detection method of mycotoxins using these platforms.

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