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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 One-pot synthesis of superparamagnetic nanoblackberries using bioligands.

2013년 2월 14일 16시 32분 21초
MAT.P-1040 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 17일 (수요일) 16:00~19:00
저자 및
연세대학교 일반대학원 화공생명공학과, Korea
Novel properties and potential applications have been emerged from monodisperse nanomaterials. Thus, the artificial synthesis of nanoparticleshas attracted great interest. Especially, magnetic nanoparticles have become important area of research because of the potential applications such as electronic devices, information storage, magnetic resonance imaging, and drug-delivery technology. Most of these approaches were focused on the synthesis of single nanoparticles. However, recent efforts have shifted to secondary structure manipulation to upgrade the properties of individual nanoparticles based on interactions between their subunits. Herein we report a novel one-pot synthetic method for the fabrication of superparamagnetic nanoblackberries (SPNBs). SPNBs are composed of assembled individual magnetic nanoparticles (MNPs) and coated with L-lysine amino acid. SPNBs were synthesized by thermal decomposition method using controlled reduction reaction between iron(III) acetylacetonate (Fe(acac)3) and diethylene glycol (DEG). L-lysine assisted the DEG mediated reduction of Fe(acac)3 to Fe3O4 and clustering of individual MNPs to SPNBs. The size, crystalline structure, and magnetic properties of the SPNBs were tunable by controlling the amount of L-lysine and reaction time. Monodisperse and single-crystalline structure of SPNBs were characterized by TEM and XRD. Superparamagnetic properties of SPNBs were investigated with a vibrating sample magnetometer. As a proof of our concept, we modified the SPNBs surface with dextran and applied to T2 contrast agent for MRI. Dextran coated SPNBs showed higher sensitivity than individual MNPs with no cytotoxicity. From this novel strategy, advanced designs and development of magnetic nanomaterials will be possible.