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학술발표회초록보기

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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Synthesis and Evaluation of Small Molecule-Peptide Conjugates as Potential Whitening Agents

등록일
2013년 2월 14일 16시 34분 42초
접수번호
1217
발표코드
BIO.P-606 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
이혜숙, 김한영*
애경산업(주) 중앙연구소, Korea
Hyperpigmentation which usually presents as age spots, uneven color, freckles and sometimes melasma has become an object of public concern. Hyperpigmentation was resulted from over-production of melanin by melanocytes within the skin, and this process was called melanogenesis. p-coumaric acid conjugated peptides were prepared by solid-phase synthesis as potential whitening agents. Their anti-melanogenic activities were performed by melanin inhibitory assay using B16F1 melanoma cell line. We found that p-coumaric acid conjugated peptides showed superior melanin inhibitory activities than arbutin. Also, through MTT assay and LDH release assay, we found that p-coumaric acid conjugated peptides showed very low cytotoxicity. We established HPLC analysis condition to identify p-coumaric acid conjugated peptides. Using this method, we found that p-coumaric acid conjugated peptides were stable in condition of high temperature (43℃) or direct sunlight. ※ Acknowledgement - This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry of Health & Welfare, Republic of Korea.(Grant No. : A103017)

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