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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The Surface Modification of Magnetite (Fe3O4) Nanoparticles by Silica (SiO2) and Polyethyleneglycol (PEG) for Intracellular Uptake [우수포스터상]

2013년 2월 14일 16시 40분 47초
MAT.P-1042 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 17일 (수요일) 16:00~19:00
저자 및
이동헌, 정 현*
동국대학교 화학과, Korea
Magnetic nanoparticles (MNPs) have been developed for a wide range of biomedical applications, such as magnetic resonance imaging (MRI) contrast-enhancement agents, drug delivery carriers and biosensors. However, most of synthetic routes for MNPs give to unsuitable for practical using due to their poor dispersibility in aqueous media, which is derived from their hydrophobic nature limited by preparing process. Therefore, surface modification is necessary to make them water-dispersible and to enhance their intracellular uptake efficiency. In this study, oleate and oleylamine capped superparamagnetic magnetite (Fe3O4) nanoparticles were synthesized by the thermal decomposition method as a core material. The resulting these MNPs were then coated with silica (SiO2) and polyethyleneglycol (PEG) derivatized phospholipid ligands to endow them with biocompatibility. The obtained products were characterized by measurements of X-ray diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM), Fourier transform infrared spectroscopy (FT-IR), and dynamic light scattering (DLS). Also, these surface modified MNPs were treated in bone marrow mesenchymal stem cells (BM-MSCs) and the cytotoxicity of them was measured by MTT assay (cell viability test). After that, these surface modified MNPs were measured Fe concentrations within cells by inductively coupled plasma-atomic emission spectrometry (ICP-AES) analysis for comparison of their uptake efficiency in cell lines depending upon the nature of coated materials and surface property.