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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The Facile Aerobic Oxidative Cyclization for One-Pot Peperation of Benzofused Heteroaromatic Compounds

등록일
2013년 2월 14일 16시 51분 40초
접수번호
1253
발표코드
ORGN.O-3 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 30분
발표형식
구두발표
발표분야
유기화학 - Oral Presentation for Young Organic Chemists
저자 및
공동저자
조연호, 천철홍*
고려대학교 화학과, Korea

Benzofused heteroaromatic compounds such as benzoxazoles and benzothiazoles have been known as a crucial building block of therapeutic important compounds, drugs and many natural products. They have been also found in material chemical such as dyes, fluorescence and sensor. Thus, many synthetic methods have been developed to efficiently synthesize these important building blocks efficiently under mild reaction conditions. Among them, aerobic oxidative cyclization of Schiff bases derived from aniline derivative (contain X at ortho position of aniline; where X = OH, SH, NH2) with aldehydes using oxygen as the terminal oxidant has received a lot of attention. Thus, we recently developed highly efficient aerobic oxidative cyclization methods from Schiff bases in the presence of a nucleophile catalyst to afford benzofused heteroaromatic compounds. Furthermore, we have developed sequential one-pot protocols for the preparation of these important compounds without isolation of imine intermediates.


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