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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Stimulation of Cardiomyogenic Gene Expression of Mesenchymal Stem Cells Cultured on Graphene

등록일
2013년 2월 14일 16시 55분 38초
접수번호
1258
발표코드
MAT.P-1049 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
4월 17일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
재료화학
저자 및
공동저자
박수범
서울대학교 화학부, Korea
Cardiomyogenic gene expressions of bone marrow-derived mesenchymal stem cells (MSCs) are enhanced when MSCs are cultured on graphene as compared to MSCs cultured on coverslips. Diverse substrates have been utilized for MSCs culture to induce their commitments toward specific tissue lineages. Recently, graphene has been suggested as a promising substrate for stem cell culture. Graphene has potential to promote specific stem cell differentiation. Herein, we showed the specifically activated cell signaling pathways that can enhance cardiomyogenic differentiation of MSCs when the cells were grown on graphene. The cell signaling pathways may have affected actin filament recruitment, cytoskeletal dynamics, and cardiomyogenic gene expression in MSCs. As a consequence, extracellular matrix (ECM) gene and cardiomyogenic lineage specific protein expression of MSCs cultured on graphene were significantly enhanced as compared to those of MSCs cultured on coverslips. Our results demonstrate the potential of graphene for stem cell research.

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