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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Protein Encapsulation within Synthetic Molecular Hosts

등록일
2013년 2월 21일 14시 25분 32초
접수번호
1400
발표코드
ORGN.O-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
금 10시 : 00분
발표형식
구두발표
발표분야
유기화학 - Oral Presentation for Young Organic Chemists
저자 및
공동저자
FUJITADAISHI
포항공과대학교 첨단재료과학부, Japan

Protein encapsulation has long attracted many chemists and biologists because of its potential to control the structure and functions of proteins, but has been a daunting challenge because of their sensitive nature and incommensurably larger size as compared with common synthetic hosts. Here, we report the encapsulation of a small protein, ubiquitin, within giant coordination cages. The protein was attached to one bidentate ligand (L) (1) and, upon addition of Pd(II) ions (M) and additional ligands (2), M12L24 coordination nanocages self-assembled around the protein (3). Due to the well-defined host framework, the protein-encapsulated structure could be well analyzed by NMR spectroscopy, ultracentrifugation, and X-ray crystallography. We demonstrated that ubiquitin (roughly 4 nm in diameter) was fully encapsulated within the 6.3 nm coordination sphere.


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