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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Alpha lipoic acid / layered metal hydroxide nanohybrids with controlled release property

2013년 2월 28일 15시 38분 47초
MAT.P-1077 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
4월 17일 (수요일) 16:00~19:00
저자 및
이지희, 김가인, 양재훈, 최진호*
이화여자대학교 화학.나노과학과, Korea
Alpha lipoic acid (ALA) is powerful antioxidant that can directly scavenge free radicals and protect cell from oxidative damage. However, ALA is photochemically unstable due to the distorted dithiolane ring which absorbs light around 330 nm. In order to solve this problem, we attempted to incorporate ALA into the interlayer of zinc based layered metal hydroxies with different layer charge density via co-precipitation and ion-exchange reaction. According to x-ray diffraction analysis, the basal spacings of the nanohybrids were expanded to ~ 2.5 nm for ZBS and ~ 2.2 nm for LDHs, which is similar regardless of synthetic methods (coprecipitation and ion-exchange). Infrared spectra show that ALA molecules in anionic form were incorporated into the interlayer space of ZBS and LDH through electrostatic interaction without any structural change. According to the thermogravimetric analysis, the thermal stability of nanohybrid was fairly improved compared to the ALA itself. UV-vis spectra of intact ALA and ALA obtained from the nanohybrids show similar shape, indicating that ALA is safely encapsulated in to the layered metal hydroxides. According to the UV-vis spectroscopic analysis and HPLC analysis, the content of ALA in nanohybrids was determined to be 28 ~ 46 wt% depending on the layer charge density of host layers. The release property and stability would be systematically discussed depending on the charge density of the inorganic host layer.