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  • 02월 28일 19시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제111회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Self-Assembled Synthetic Ion Channels: Design, Characterization and Biomedical Applications

2013년 3월 18일 17시 49분 50초
KCS-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 09시 : 10분
[KCS-ACR joint Symposium] International Frontier Scientists Symposium on "Impact of Chemistry on Biology" hosted by KAST and co-organized by KCS & ACR
저자 및
Dan Yang
Department of Chemistry, The University of Hong Kong, Hong Kong, China, Hong Kong
※ 국외소속으로 등록된 저자의 승인여부는 최소 3일이내 발표자 email로 알려드립니다.
승인 1건
Ion transport across membranes is one of the most important biological processes of all living cells. Ion channel proteins that selectively regulate ion flows are involved in many physiological processes ranging from neuronal signaling, muscle contraction, and cardiovascular function to immune response. Dysfunction of ion channels has been associated with many severe human diseases such as cystic fibrosis, asthma, hypertension, epilepsy and myocardial infarction. Therefore, developing drugs that modulate the functions of ion channels or regulate ion transport across cell membranes have received significant attentions in pharmaceutical industry. Each year over US$6 billion are generated from the sales of drugs associated with ion channel functions. Most of those drugs affect the functions of natural calcium, sodium or potassium channels through direct binding. In this talk, I will report our recent discovery of small molecules that self-assemble into synthetic ion channels that transport small anions or cations across biological membranes and their potential biomedical applications. These synthetic ion channels can mediate ion flow across plasma membranes of living cells with remarkably high efficiency, independent of natural ion channels. They are easy to synthesize and their pharmacological properties can be readily modified for therapeutic applications. Explorations on their potential biomedical applications will also be presented.