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  • 09월 06일 11시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Discovery of Novel Therapeutic Agents using Chemical Biology and Molecular Diversity

2013년 8월 23일 11시 56분 04초
ORGN3-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 17시 : 10분
유기화학 - The Future of Organic Chemistry
저자 및
서울대학교 화학부, Korea
The importance of molecular diversity has been clearly recognized to identify specific bioactive small molecules for the elucidation of mysterious biological processes. The diversity-oriented synthesis (DOS) was introduced for efficient population of molecular diversity in untapped chemical space using complexity-generating synthetic route. To maximize the molecular diversity with high relevance in biological space, we pursued privileged-substructure-based DOS (pDOS) strategy to emphasize the importance of maximized skeletal diversity through the creative reconstruction of core skeletons containing privileged substructures. Our divergent pDOS strategy can provide an efficient approach for the discovery of novel small-molecule modulators with excellent specificity in chemical biology and drug discovery. Secondly, a systematic study of Seoul-Fluor will be presented. During our continuous efforts on the construction of drug-like small-molecule libraries using pDOS strategy, we aimed to develop a novel fluorescent core skeleton for the development of bioprobes, applicable for image-based screening. Seoul-Fluor analogs were successfully applied in HCS. Lastly, we developed a new target identification platform, FITGE, which aims to preserve protein-small molecule interactions under the intact cellular environment. After a series of failures using conventional target ID methods, we successfully identified the protein target of anti-proliferative compound with FITGE only under the live cell condition and observed the environment-dependent binding events of a functional small molecule by direct comparison between live cells and cell lysates.