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학술발표회초록보기

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제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Development of the Metal-Catalyzed Direct C-H Amination Reactions

등록일
2013년 8월 23일 14시 29분 50초
접수번호
0153
발표코드
ORGN3-1 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 16시 : 10분
발표형식
심포지엄
발표분야
유기화학 - The Future of Organic Chemistry
저자 및
공동저자
장석복
한국과학기술원(KAIST) 화학과, Korea
Aryl amines are a key synthetic unit widely utilized in organic synthesis, coordination chemistry, materials science and pharmaceutical industry. Current routes to those compounds require either prefunctionalized starting materials or external oxidants, thus inevitably generating stoichiometric amounts of side wastes. We have developed direct amidation and amination reactions of arene carbon-hydrogen (C-H) bonds using sulfonyl and aryl azides as the source of the nitrogen group to release molecular nitrogen as the single by-product. The reaction is catalyzed by a cationic rhodium complex under external oxidant-free conditions, and a broad range of chelate group-containing arenes are selectively amidated and aminated with excellent functional group tolerance, thereby opening a new avenue to environmentally benign carbon-nitrogen (C-N) bond formation which can be immediately applied in synthetic chemistry, medicinal, and materials science.

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