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학술발표회초록보기

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  • 09월 06일 11시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Lab-on-a-disc for Analytical Chemistry

등록일
2013년 8월 26일 13시 55분 38초
접수번호
0214
발표코드
ANAL1-5 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
목 11시 : 10분
발표형식
심포지엄
발표분야
분석화학 - KCS-JASIS Joint Symposium: Advanced Separation Science
저자 및
공동저자
조윤경*, 김태형, 박양석, 김유빈
울산과학기술대학교(UNIST) 생명공학과, Korea

We present a novel fully integrated centrifugal microfluidic device, “Lab-on-a-disc”, for various kinds of applications in analytical chemistry. In biomedical applications, a bead-based enzyme-linked immune-sorbent assay was fully integrated on a disc starting from whole blood for the analysis of multiple protein biomarkers for cardiovascular diseases [1]. The detection sensitivity could be enhanced significantly by using electrochemical detection on a spinning disc and employing nanomaterials such as electrospun nanofibers [2]. In molecular diagnostics, pathogen specific DNA could be extracted from whole blood on a disc within 12 minutes [3] and for the food safety application, a further research fully integrated all the process for Salmonella detection from the milk within 30 minutes by using an isothermal DNA amplification method, Recombinase Polymerase Amplification. Lab-on-a-disc was also employed to automate solid phase extraction of caffeine from real beverages such as a coffee or a soft drink for the quantitative analysis of caffeine concentration [4]. The “Lab-on-a-disc” technology is advantageous because of the capability to integrate and automate all the process into a disc-shaped device with simple, size-reduced, and cost-efficient instrumentation. Integration with microfluidic technology allows more precise control of fluids while also reducing the reagent consumption, the required analysis time and handling errors. We believe these approaches will not only improve the performance of the target analysis but also potentially have great impact on global healthcare. References [1] J. Park et al. Anal. Chem., 84, 2133, 2012 [2] T. Kim et al, Lab Chip, 13, 3747, 2013 [3] Y. Cho et al., Lab Chip, 7, 565, 2007 [4] W. Xu et al., Scientific Reports, 3, 2255


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