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제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Human ABC Transporters and Pharmacogenomics

2013년 8월 29일 16시 46분 49초
MEDI-4 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
목 16시 : 15분
의약화학 - Current Trends in Medicinal Chemistry: Orphan Drugs
저자 및
연세대학교 의과대학 약리학교실, Korea
ATP-binding cassette (ABC) transporters constitute a superfamily of membrane proteins. The ABC proteins protect cells from a wide range of toxic compounds, and regulate basic biologic processes of essential organs. Consequently, mutations affecting ABC-transporters have been found to be the underlying causes for a large number of human inherited diseases including cystic fibrosis. Currently, 49 ABC transporter genes were identified in human genome and classified into 7 subfamilies according to their sequence homologies. The multi-drug resistance 1 (MDR1) and multidrug resistance proteins (MRPs) genes were originally identified as a gene that confers multi-drug resistance to cancer cells. They have a physiological role of protecting cells and organisms from various toxic substances including commonly prescribed medications. Thus, identifying the individual genetic variations of these transporters carries significant meaning in pharmacotherapy of post-genomic era, since such genetic variants are likely to be an important source for the inter-individual variability in toxicity and response of many drugs. Our results of genetic association studies revealed that genetic variations in the ABC transporters are associated with drug response and toxicity of antidepressants, antiepileptics and cardiovascular agents. Further identification of the functional genetic variations in ABC transporters and other major drug-response genes using the state-of-the-art technologies will improve the predictive value of genetic tests for tailored drug therapy.