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학술발표회초록보기

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  • 09월 06일 15시 이후 : 초록수정 불가능, 일정확인 및 검색만 가능

제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Suzuki-Miyaura coupling reaction in the microreactor wall-coated with Pd-catalyst

등록일
2013년 8월 29일 16시 48분 15초
접수번호
1173
발표코드
ORGN.P-859 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
유기화학
저자 및
공동저자
김미진, 박정현, 박찬필1,*
충남대학교 분석과학기술대학원 분석과학기술학과, Korea
1충남대학교 분석과학기술대학원, Korea
The palladium-catalyzed Suzuki-Miyaura coupling reaction is one of the most powerful and convenient methods for the preparation of biaryl and alkene derivatives that are structural components of natural products, agrochemicals, pharmaceuticals, and polymers. Batch reaction and microchemical reaction can have several differentias. Some catalyst used in traditional batch systems should be modified in microchemical reactions. Even though Pd/C catalyst with advantages of its availability, reusability, and easy handling showed excellent results in broad batch reactions, the application in some microchemical reaction was restricted due to the reactor channel clogged with solid catalyst. Herein, we report a microchemical system wall-coated with Pd catalyst, which has the advantages of thermal, chemical stability, and cost-effectiveness. No limitation compared with traditional Pd/C catalyst is showed, excellent yield and selectivity is observed. A ligand is firstly introduced on inner wall of commercially available silica tube, which binds a palladium catalyst for repeated application in Suzuki-Miyaura coupling reaction. We could simply get the various biaryl compounds with easy handling of reaction parameters including temperature, solvent, and reaction time.

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