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제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Study of lipid flip-flop

등록일
2013년 8월 29일 16시 57분 33초
접수번호
1190
발표코드
BIO.P-591 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
Phan Dinh Minh, 신관우1,*
서강대학교 화학과, Korea
1서강대학교 화학과 및 바이오융합과정, Korea
The transbilayer movement of phospholipids in cellular membranes, also known as lipid flip-flop or translocation, is an area of significant biological importance. It has long been believed that the exchange of lipids between the inner and outer leaflets of cellular membranes could only occur by a protein-mediated process. However, cells also use passive transport mechanism that facilitates the migration of lipids from one leaflet to the other without proteins. In this study, we aim at the mechanism of lipid flip-flop phenomenon at molecular level. We would like to investigate the effect of charge lipids and unsaturated lipids, which regulate many biological functions and are strongly related to the specific structure of bilayer membrane, 1) whether they cause the lipid disorder to facilitate the flip-flop, 2) how the negative charge is managed to move across the hydrophobic region in the intermediate structure. Our project is still undergoing the first stage, to prepare a well-organized bilayer structure by the Langmuir-Blodgett/Langmuir-Schaeffer method. The structures of lipid bilayers were characterized by X-ray reflectivity and Atomic Force Microscopy.

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