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제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 A Novel Homogeneous Assay for Simultaneous Determination of Fluoroquinolones in Water based on Upconversion Fluorescence Resonance Energy Transfer

등록일
2013년 8월 29일 17시 00분 14초
접수번호
1200
발표코드
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발표시간
10월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
분석화학
저자 및
공동저자
GerelkhuuZayakhuu, 강지훈, 이용일*, Zhen Zhang1
창원대학교 화학과, Korea
1school of the environment ,Jiangsu University, China
※ 국외소속으로 등록된 저자의 승인여부는 최소 3일이내 발표자 email로 알려드립니다.
승인 1건
A novel homogeneous method for simultaneous sensing of trace fluoroquinolones (FQs) in water using upconversion fluorescence resonance energy transfer (FRET) was developed. Lanthanide-based upconversion nanophosphors(UCPs) have attracted much attention because of wide application in biological labeling, sensing, and imaging.It was attributed to its unique characteristics of low toxicity, nearly-zero background auto-fluorescence, narrow emission band, high photoluminescence intensity, and photostability. Although the surface functionalization of UCPs with good hydrophilic and strong luminescence inaqueous solution has been performed, the application in biological assays is still few, especially for organic pollutants in foodstuffs and environmental waters. We present the facile synthesis of monodisperse, size-tunable,and highly efficient UCPs(β-NaLuF4:Gd,Yb,Er3+) linked with -COOH groups which can be used as an donor after conjugation with our produced FQs monoclonal antibody. The corresponding antigens labeled gold nanoparticles (AuNPs) was treated as an acceptor. In competitive reaction, dissolved FQs and labeled AuNPs competed each other to combine with FQs antibodies labeled UCNPs. The original green light was quenched by the acceptorwhen exited by Near-infrared light (980 nm) to donor, and the intensity shows the linear correlationship with the concentration of FQs in water. Keywords: Upconversion nanoparticles, fluoroquinolones, fluorescence resonance energy transfer (FRET), near-infrared light

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