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제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 The anti-inflammatory effect of Scutellaria baicalensis through control of immune system in Raw264.7 cells

등록일
2013년 8월 29일 17시 00분 20초
접수번호
1201
발표코드
BIO.P-592 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
박혜정, 김문무*
동의대학교 화학과, Korea
Immune system protects the body from various diseases caused by bacterial infection and cancer by elimination of internal mutated cells. However, the abnormal immune system induces senile diseases like rheumatoid arthritis through chronic inflammation. Therefore, the purpose of this study is to investigate anti-inflammatory effect of Scutellaria baicalensis that contains baicalin as an effective gradient. First of all, MTT assay was carried out to evaluate the cytotoxicity of Scutellaria baicalensis hot water extracts (SBWE) in Raw264.7 cells. There was no cytotoxicity below 40 ㎍/mL of SBWE. It was also observed that SBWE at 20 ㎍/mL inhibited phagocytosis by 20 %. In addition, SBWE at 40 ㎍/mL reduced the amount of nitric oxide produced by macrophage by 40 %. Furthermore, the content of tumor necrosis factor-alpha (TNF-α) was decreased in the presence of SBWE a dose dependent manner. SBWE also inhibited the production of interleukin-1 beta (IL-1β) in a time course experiment. The expression level of cyclooxynase-2 was remarkably decreased by treatment with SBWE at 20 ㎍/mL. Therefore, above results could provide an evidence that SBWE influence anti-aging through modulation of immune system.

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