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제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Genotype Analysis of Estrogen Receptor α Gene Polymorphisms Associated with Endometriosis in Korean Women

등록일
2013년 8월 29일 17시 21분 11초
접수번호
1222
발표코드
BIO.P-593 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
문명진, 조민호, 윤일규, 김진호, 최영훈, 장원철1,*
단국대학교 화학과, Korea
1단국대학교 자연과학대학, Korea
Endometriosis is common estrogen-dependent gynecological diseases related with interactions of dietary, genetic causes, social and environmental factors. The high prevalence approaches 5-15% in premenopausal women and 30% in infertile women and it is unusually occurred even after the onset of menopause. Estrogen receptor α is a higher affinity for estrogen, it is the predominant form in normal endometrium. Several single nucleotide polymorphisms (SNPs) in the estrogen receptor α gene have been identified. Especially, association between estrogen receptor α polymorphisms (PvuII and XbaI) and breast cancer, Parkinson`s disease, bone mineral density and ovarian cancer have identified. In addition, many epidemiological studies suggested that PvuII and XbaI polymorphisms of estrogen receptor α were associated with increased risk of endometriosis. Our present study, we investigated to association between estrogen receptor α polymorphisms (PvuII and XbaI) and endometriosis by PCR-RFLP method. Our data show that, mutant types of PvuII and XbaI polymorphisms had a high odds ratio compared with the wild type. The odds ratio of CC type of PvuII was 1.429 (OR= 1.429, 95% CI= 0.287-1.121, p-value= 1.000), AG type of XbaI was 1.796 (OR= 1.796, 95% CI= 0.611-5.276, p-value: 0.419), GG type of XbaI was 2.211 (OR= 2.211, 95% CI= 0.185-26.4, p-value: 0.607). In conclusion, we have found differences between cases and controls in the frequencies of the estrogen receptor α gene polymorphisms. However, statistical data is no associated with endometriosis due to small sample size.

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