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제112회 대한화학회 학술발표회, 총회 및 기기전시회 안내 Investigation of ABCG2 Gene Q141K Polymorphism Associated with Gout Patients in Korean

등록일
2013년 8월 29일 17시 30분 05초
접수번호
1225
발표코드
BIO.P-594 이곳을 클릭하시면 발표코드에 대한 설명을 보실 수 있습니다.
발표시간
10월 16일 (수요일) 16:00~19:00
발표형식
포스터
발표분야
생명화학
저자 및
공동저자
최영훈, 조민호, 윤일규, 김진호, 문명진, 장원철1,*
단국대학교 화학과, Korea
1단국대학교 자연과학대학, Korea
The gout is the most common cause of inflammatory arthritis in men over the age of 40 years. The prevalence and incidence of gout have increased in recent decades. The Gout is a disorder that is related to deposition of uric acid crystals caused by high level uric acid in the blood. The uric acid is the byproduct of purine nucleotide catabolism. ABCG2 protein included in ATP-binding cassette (ABC) transporters superfamily. The major role of ABCG2 proteins are transport diversity molecule across extra-intra cellular membrane and purine nucleoside analogues. ABCG2 protein is encoded to ABCG2 gene. ABCG2 gene is located in 4q22 and contains 16exons consisting 655 amino acids. Many single nucleotide polymorphisms in ABCG2 gene have identified. Among these SNPs, Q141K (rs2231142) polymorphism of ABCG2 gene was associated with gout in several epidemiological studies. In this study, we investigated to Q141K of ABCG2 gene associated with Korean gout patients by genotyped using the TaqMan assay.

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